![]() ![]() Of the nine possible diplotypes, AA/AG, AA/GG, and AG/GG were not found, in concordance with the hypothesis that the G allele of c.*96A>G does not occur in the absence of the G allele of c.1055A>G. The variants were found to be in linkage disequilibrium (D' = 1). The inference of haplotypes resulted in 312 (0.78) AA, 72 (0.18) GA, and 16 (0.04) GG haplotypes. The variant c.*96A>G was also in HWE ( p = .2105): 185 individuals (0.925) with the AA genotype, 14 (0.07) with AG, and 1 (0.005) with (GG), with a frequency of 0.04 (4%) for the polymorphic allele. For the (p.Asn352Ser) variant, we found 126 (0.63) individuals with the AA genotype, 62 with AG (0.31) and 12 with GG (0.06) the frequency of the polymorphic allele was 0.215 (86 alleles, 21.5%), and the variant was in HWE ( p = .2484). The enzymatic activity of ASA was determined to be 1.74–2.09 nmol/mg protein/min and later correlated with genotypes and haplotypes. ![]() Haplotypes were constructed using Arlequin v.10.04, and linkage disequilibrium analysis was performed with Cube X. Genotypes were confirmed by semi-automated Sanger sequencing. Two-hundred apparently healthy individuals were included to determine the enzymatic activity of ASA in leukocytes by spectrophotometric analysis, and identification of the PD-ASA alleles was performed by PCR-RFLP assays. To determine the activity of Arylsulfatase A and to identify variants and haplotypes in the ARSA gene in Mexican individuals with pseudodeficiency. PD-ASA is associated with the c.1055A>G (p.Asn352Ser) (rs2071421) and c.*96A>G (rs6151429) variants, which have an estimated frequency of 2% in the population. ASA pseudodeficiency (PD-ASA) is a biochemical condition that substantially diminishes ASA activity but is not associated with clinical manifestations. The Payroll Plus team would be pleased to provide you with any support should you have any questions.Metachromatic Leukodystrophy (MLD, OMIM 250100) is a neurodegenerative disease caused by mutations in the ARSA gene (OMIM 607574) that lead to deficiency in Arylsulfatase A (ASA). Once the payment is made, it will be assumed that the agreement with the Mexican Social Security Institute (IMSS), is accepted. ![]() Once the institute verifies the information, the employer will receive by e-mail the draft agreement along with the payment slip which can be paid through a SPEI transfer to the account: 021180550300067765, bank: HSBC. For public entities or for acts of administration it must be specific in order to process the application).ĥ.A separate sheet requesting authorization for payment installments and the periods for making such. Power of attorney from legal representative (only the page that indicates the power conferred on the legal entity. Articles of incorporation of legal entity (only those pages that indicate the original company name, as well as those that have the folio of the Public Registry of Property and Commerce). Officially valid identification from employer or legal representativeģ. The following documentation must be submitted:Ģ. It is therefore not necessary to go the regional office. If the employer chose to request the agreement, then the information listed below must be sent using the previously mentioned e-mail. The deferment period with monthly interest is chosen among the following periods: The institute provides to the employers the following phone number: “800-6232-323”, and e-mail address: “ to provide support for entering into a simplified installment agreement, taking into consideration the principal amount covered by the employer is 20% of the total dues of the employer, and 100% of the workers´ dues. The objective of the Mexican Social Security Institute is to enter into a payment installment agreement with interested employers who are not required to cover tax interest, and who are not subject to fines, since the employer freely complies with its obligations with regards to social security which originates from the health emergency per the Agreement of the General Health Council, published on March 30 of the current year in the Official Gazette of the Federation. 213/2020 regarding simplified installment payments, foreseeing that some employers will have difficulty in making payments for the employer/worker dues. Stemming from the Covid-19 health emergency, the Mexican Social Security Institute released statement No. ![]()
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